![]() ![]() HEP is very rare, with only about 40 cases reported worldwide. People may also experience hair growth (hypertrichosis), brown- or red-colored teeth (erythrodontia), and red- or purple-colored urine. Skin sensitivity to light often leads to severe blistering, sometimes with mutilation or loss of fingers or facial features. Hepatoerythropoietic porphyria (HEP) is the autosomal recessive form of familial porphyria vutanea tarda (f-PCT) and presents with similar symptoms. Men and women can both be affected, but PCT is most common in women over age 30. PCT is mostly an acquired disease, but some people have a genetic deficiency of the enzyme uroporphyrinogen decarboxylase (UROD) that contributes to the development of PCT. It’s associated with extreme sensitivity to sunlight and painful, blistering lesions on the skin. Porphyria cutanea tardaĪccording to the American Porphyria Foundation, Porphyria cutanea tarda (PCT) is the most common type of porphyria. Blistering and lesions can often occur from exposure.ĬEP is a very rare disorder with just over 200 cases having been reported worldwide. The most common symptom is hypersensitivity of the skin to sunlight and some forms of artificial light. Congenital erythropoietic porphyriaĬongenital erythropoietic porphyria (CEP) results from the deficient function of the enzyme uroporphyrinogen lll cosynthase (UROS). Reports suggest that women are more likely to carry the gene mutation. VP is more common in South Africa in people of Dutch ancestry with up to 3 in 1,000 people in the white population affected. Sun sensitivity including blistering skin is the most common skin symptom of Variegate porphyria (VP).Īcute attacks of VP often begin with abdominal pain. Symptoms can vary greatly including skin symptoms, neurological symptoms, or both. Similar to AIP, symptoms may not occur unless triggered by behavioral, environmental, or hormonal changes.īoth men and women are affected equally, though women are more likely to experience symptoms. ![]() Hereditary coproporphyria (HCP) is characterized by a deficiency of the enzyme coproporphyrinogen oxidase (CPOX). ![]() confusion, hallucinations, and seizures.Women going through puberty are especially likely to have symptoms. Many with an HMBS gene mutation don’t show symptoms unless triggered by one or more of the following: Acute intermittent porphyriaĪcute intermittent porphyria (AIP) is a deficiency of the enzyme hydroxymethylbilane synthase (HMBS). Symptoms present as an acute attack, often as severe abdominal cramping with vomiting and constipation. Only about 10 cases have been reported worldwide, and all have been in males. Delta-aminolevulinate-dehydratase deficiency porphyriaĪLAD porphyria (ADP) is a deficiency of the enzyme delta-aminolevulinic acid (ALA) and is one of the more severe and rare forms of porphyria. They’re associated with light sensitivity. They’re associated with symptoms such as abdominal pain and problems with the central nervous system.Įrythropoietic forms are caused by problems in red blood cells. Hepatic forms of the disorder are caused by problems in the liver. I don't fully understand it but Swifto has made several posts about it.Īnd this will have no effect on progesterone receptor at all?īut if prolactin sides have already become apparent then caber etc can then be used to regulate prolactin? Best course of action is to control E with AI (and tamox if gyno starts) but have a dopamine agonist on hand just in case.There are several types of porphyria, which are classified into two categories: I think it's called the long feedback mechanism. So does this then mean that it is now understood that nolvadex CAN be used to combat progeterone by blocking the estrogen to begin with? Yes, but not just nolva, the idea is to control estrogen (preferably with an AI) as it regulates prolactin. ![]() Hmmmm just read the thread at top mabey I shouldnt of been so quick to dismiss it orginally, to the OP I apologise Then, Anthony Roberts caused the whole misconception to spread like wildfire on the internet and the idea is still parroted all over the place. None taken, but really? everything I have ever read states what I claimed, it may be outdated (and I'm searching now) but I'm yet to come across a study to show this I think the whole tamox upregulates the PgR receptor theory came from studies done on females with breast cancer who were taking massive doses of tamox. ![]()
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